{"id":36176,"date":"2024-10-28T01:07:51","date_gmt":"2024-10-28T01:07:51","guid":{"rendered":"https:\/\/www.writemyessays.app\/blog\/questions\/the-advanced-ai-now-in-use-of-protein-structure-prediction-with-alphafold-protein-the-possible-breakthrough\/"},"modified":"2024-10-28T01:07:51","modified_gmt":"2024-10-28T01:07:51","slug":"the-advanced-ai-now-in-use-of-protein-structure-prediction-with-alphafold-protein-the-possible-breakthrough","status":"publish","type":"questions","link":"https:\/\/www.writemyessays.app\/blog\/questions\/the-advanced-ai-now-in-use-of-protein-structure-prediction-with-alphafold-protein-the-possible-breakthrough\/","title":{"rendered":"The Advanced AI now in use of Protein structure prediction with AlphaFold protein: The possible breakthrough"},"content":{"rendered":"<p>Write review paper on :<\/p>\n<div>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\"><span style=\"cursor: auto; color: inherit;\">&#8211;<span style=\"font-size: 7pt; line-height: normal; cursor: auto; color: inherit;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br \/>\n<\/span><\/span><\/span><b style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">AlphaFold basic work overview: <\/span><\/b><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">Analysing<br \/>\nlong-range protein sequences, increasing dependability, and producing highly<br \/>\ncomputationally predicted protein structures with amino acid sequences to 3D<br \/>\nprotein structures (Jumper et al., 2021).<\/span><\/p>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">&nbsp;<\/span><\/p>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\"><span style=\"cursor: auto; color: inherit;\">&#8211;<span style=\"font-size: 7pt; line-height: normal; cursor: auto; color: inherit;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br \/>\n<\/span><\/span><\/span><b style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">Computational functional basics<\/span><\/b><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">:<br \/>\nAlphaFold prevails over previous protein structure prediction methods by using<br \/>\ndeep neural networks with hundreds of layers database, dilated convolutions to<br \/>\nmodel long-range interactions across entire protein sequences, and advanced<br \/>\ncomputational optimizations to handle long sequences<\/span> <span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">(Evans<br \/>\net al., 2021). <\/span><\/p>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">&nbsp;<\/span><\/p>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\"><span style=\"cursor: auto; color: inherit;\">&#8211;<span style=\"font-size: 7pt; line-height: normal; cursor: auto; color: inherit;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br \/>\n<\/span><\/span><\/span><b style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">Efficiently Improvement in protein<br \/>\ndatabase: <\/span><\/b><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">Present software gives open access to a large range of<br \/>\nspecies that contain specific proteins, for example. Enter only the protein<br \/>\nsequence to obtain the name of the organism, the sequence match, the e-value,<br \/>\nthe gene name, and the protein name&nbsp;For instance, Cyclic kinase 2 for<br \/>\nSequence of &#8220;MENFQKVEKIGEGTYGVVYKARNKLTGEVVALKKIRLDTETEGVPSTAIREIS&#8221; (Varadi<br \/>\net al., 2022)<b style=\"cursor: auto; color: inherit;\"><\/b><\/span><\/p>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">&nbsp;<\/span><\/p>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">Multimer upgrade: allowing multichain<br \/>\ninteraction and visual of it allowing deep insight of cellular function (Evans<br \/>\net al., 2021)<b style=\"cursor: auto; color: inherit;\"><\/b><\/span><\/p>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">&nbsp;<\/span><\/p>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\"><span style=\"cursor: auto; color: inherit;\">&#8211;<span style=\"font-size: 7pt; line-height: normal; cursor: auto; color: inherit;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br \/>\n<\/span><\/span><\/span><b style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">Uses in field:<\/span><\/b><\/p>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">&nbsp;<\/span><\/p>\n<p style=\"margin-left: 72pt; cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\"><span style=\"cursor: auto; color: inherit;\">o<span style=\"font-size: 7pt; line-height: normal; cursor: auto; color: inherit;\">&nbsp;&nbsp;<br \/>\n<\/span><\/span><\/span><u style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">Disease research<\/span><\/u><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">:<\/span><\/p>\n<p style=\"margin-left: 108pt; cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\"><span style=\"cursor: auto; color: inherit;\">\u00a7<span style=\"font-size: 7pt; line-height: normal; cursor: auto; color: inherit;\">&nbsp; <\/span><\/span><\/span><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">Treatment<br \/>\noptions are expanded by the machine&#8217;s ability to anticipate the pathogenicity<br \/>\nof many diseases, such as paralysis through the identification of Alsin<br \/>\nprotein. For other disorders, research is still under progress<\/span>. <span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">(Liu<br \/>\net al., 2021)<\/span><\/p>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">&nbsp;<\/span><\/p>\n<p style=\"margin-left: 72pt; cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\"><span style=\"cursor: auto; color: inherit;\">o<span style=\"font-size: 7pt; line-height: normal; cursor: auto; color: inherit;\">&nbsp;&nbsp;<br \/>\n<\/span><\/span><\/span><u style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">Could be used in Drug research<\/span><\/u><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">:<\/span><\/p>\n<p style=\"margin-left: 108pt; cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\"><span style=\"cursor: auto; color: inherit;\">\u00a7<span style=\"font-size: 7pt; line-height: normal; cursor: auto; color: inherit;\">&nbsp; <\/span><\/span><\/span><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">Even<br \/>\nwhile some research limited access to the protein&#8217;s structural details (still<br \/>\nin process), this approach sped up the process of developing customized drugs<br \/>\nthat target particular pathogenic proteins. (Rosie et al., 2022)<\/span><\/p>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">&nbsp;<\/span><\/p>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\"><span style=\"cursor: auto; color: inherit;\">&#8211;<span style=\"font-size: 7pt; line-height: normal; cursor: auto; color: inherit;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br \/>\n<\/span><\/span><\/span><b style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">Upcoming expected upgrades<\/span><\/b><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">:<br \/>\nImprovement in disordered proteins, AI-based drug Design, Proteomics for<br \/>\ndiverse organisms expanding organism and structural coverage (Jumper et al.,<br \/>\n2021).<\/span><\/p>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">&nbsp;<\/span><\/p>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\"><span style=\"cursor: auto; color: inherit;\">&#8211;<span style=\"font-size: 7pt; line-height: normal; cursor: auto; color: inherit;\">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;<br \/>\n<\/span><\/span><\/span><b style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">Challenges such as disordered protein<\/span><\/b><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\">:<br \/>\nPhysical constraints that impede disordered proteins from producing regular<br \/>\nresults. Currently able to predict multichain interactions and single folds<br \/>\n(Liu et al., 2021)<\/span><\/p>\n<p style=\"cursor: auto; color: inherit;\"><span style=\"font-size: 12pt; line-height: 107%; cursor: auto; color: inherit;\"><br \/><\/span><\/p>\n<p style=\"cursor: auto; color: inherit;\">INSTRUCTION:&nbsp;<\/p>\n<p style=\"cursor: auto; color: inherit;\"><\/p>\n<p style=\"cursor: auto; color: inherit;\">Write a Mini review;<\/p>\n<p style=\"cursor: auto; color: inherit;\">&nbsp; Title<\/p>\n<p style=\"cursor: auto; color: inherit;\">&nbsp;\u2013 describes the mini-review<br \/>\nIntroduction&nbsp;<\/p>\n<p style=\"cursor: auto; color: inherit;\">\u2013 provides appropriate background to the topic. This section should set up<br \/>\nthe rationale for the review and often concludes with a thesis statement. \u201cIn this review,<br \/>\nwe will highlight&#8230;.\u201d.<br \/>\n[other headings as appropriate]&nbsp;<\/p>\n<p style=\"cursor: auto; color: inherit;\">\u2013 create logical subdivisions for your mini-review to<br \/>\nprovide structure.&nbsp;<\/p>\n<p style=\"cursor: auto; color: inherit;\"><\/p>\n<p style=\"cursor: auto; color: inherit;\">Conclusions \u2013 state the major conclusions of your review<br \/>\nReferences \u2013 use the referencing style and citation style of the journal,&nbsp;<\/p>\n<p style=\"cursor: auto; color: inherit;\"><\/p>\n<p style=\"cursor: auto; color: inherit;\">and citation: needs way more citation and articles than I already provided<\/p>\n<p style=\"cursor: auto; color: inherit;\"><\/p>\n<p style=\"cursor: auto; color: inherit;\">Please use Times New<br \/>\nRoman 12 pt (or Arial 11 pt). There should be no title page, but include a descriptive title at the top of<br \/>\nthe page, and your name and student number in the header. You may include figures and tables that<br \/>\nsummarize important information or concepts. These should be your figures and tables.<br \/>\nReferences should be formatted in the style of the journal, Genomics. There is no limit to the number<br \/>\nof references, but you may not use web pages or web-only sources. All references should come from<br \/>\nthe primary literature. Use Pubmed for your searches if you do not have another preferred database:<br \/>\nhttps:\/\/pubmed.ncbi.nlm.nih.gov\/.&nbsp;<\/p>\n<p style=\"cursor: auto; color: inherit;\"><\/p>\n<p style=\"cursor: auto; color: inherit;\">Web of Science is another excellent database since it allows you<br \/>\nto see who has cited a particular article.&nbsp; &nbsp;<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>Write review paper on : &#8211;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; AlphaFold basic work overview: Analysing long-range protein sequences, increasing dependability, and producing highly computationally predicted protein structures with amino acid sequences to 3D protein structures (Jumper et al., 2021). &nbsp; &#8211;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; Computational functional basics: AlphaFold prevails over previous protein structure prediction methods by using deep neural networks with hundreds [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":[],"disciplines":[40],"paper_types":[],"tagged":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/questions\/36176"}],"collection":[{"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/questions"}],"about":[{"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/types\/questions"}],"author":[{"embeddable":true,"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/comments?post=36176"}],"version-history":[{"count":0,"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/questions\/36176\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/media?parent=36176"}],"wp:term":[{"taxonomy":"disciplines","embeddable":true,"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/disciplines?post=36176"},{"taxonomy":"paper_types","embeddable":true,"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/paper_types?post=36176"},{"taxonomy":"tagged","embeddable":true,"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/tagged?post=36176"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}