{"id":18953,"date":"2024-04-02T10:25:15","date_gmt":"2024-04-02T10:25:15","guid":{"rendered":"https:\/\/www.writemyessays.app\/blog\/questions\/temporal-dynamics-of-higher-order-aberrations-in-the-human-eye-a-comprehensive-study-across-morning-and-evening\/"},"modified":"2024-04-02T10:25:15","modified_gmt":"2024-04-02T10:25:15","slug":"temporal-dynamics-of-higher-order-aberrations-in-the-human-eye-a-comprehensive-study-across-morning-and-evening","status":"publish","type":"questions","link":"https:\/\/www.writemyessays.app\/blog\/questions\/temporal-dynamics-of-higher-order-aberrations-in-the-human-eye-a-comprehensive-study-across-morning-and-evening\/","title":{"rendered":"Temporal Dynamics of Higher Order Aberrations in the Human Eye: A Comprehensive Study Across Morning and Evening"},"content":{"rendered":"\n\n\n\n<\/colgroup>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
\n

\n\t\t\tStudy description<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tTitle<\/b><\/p>\n<\/td>\n

\n

\n\t\t\tTemporal
\n\t\t\tDynamics of Higher Order Aberrations in the Human Eye: A
\n\t\t\tComprehensive Study Across Morning and Evening<\/span><\/span><\/span><\/span><\/span>
\n\t\t\t<\/span>\n\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tExaminer<\/b><\/span><\/p>\n<\/td>\n

\n

\n\t\t\tIlles Tibor<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tBackground of the study topic<\/b><\/p>\n<\/td>\n

\n

\n\t\t\tThis
\n\t\t\tstudy delves into the dynamic nature of higher order aberrations
\n\t\t\t(HOAs) in the human eye at different times of the day: morning and
\n\t\t\tevening. HOAs are optical imperfections that persist even after
\n\t\t\tcorrecting for spherical defocus and astigmatism, affecting
\n\t\t\tretinal image quality. With evidence suggesting that visual
\n\t\t\texperiences influence ocular growth, we aim to explore whether
\n\t\t\tvariations in HOAs during different times of the day contribute to
\n\t\t\tthe regulation of eye growth and refractive error development.
\n\t\t\tUnderstanding these temporal fluctuations in HOAs could provide
\n\t\t\tvaluable insights for refining strategies to manage refractive
\n\t\t\terrors and optimizing visual performance.<\/span><\/span><\/span><\/span><\/span>
\n\t\t\t<\/span>\n\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tStudy description<\/b><\/span><\/p>\n<\/td>\n

\n

\n\t\t\tExplore
\n\t\t\tthe fluctuating optics of the human eye throughout the day in our
\n\t\t\tstudy. Investigating morning and evening variations, we aim to
\n\t\t\tuncover insights into how these optical imperfections impact eye
\n\t\t\tgrowth and refractive error development. <\/span><\/span><\/span><\/span><\/span>\n\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t
<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tStudy definitions<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tStudy design<\/b><\/span><\/p>\n<\/td>\n

\n

\n\t\t\tAnalytical,
\n\t\t\tLongitudinal, Prospective, Experimental, Monocentric<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tPrimary aim<\/b><\/span><\/p>\n<\/td>\n

\n

\n\t\t\tDifference
\n\t\t\tin HOA<\/span>
\n\t\t\tin the human eye vary throughout the day<\/span><\/span><\/span><\/span><\/span>
\n\t\t\t<\/span>\n\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tPrimary hypothesis<\/b><\/span><\/p>\n<\/td>\n

\n

\n\t\t\tThere
\n\t\t\tis no difference in HOA in the human eye vary throughout the day <\/span>\n\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tSecondary aim(s)<\/b><\/span><\/p>\n<\/td>\n

\n

\n\t\t\tDifferences
\n\t\t\tin higher order aberrations (HOAs) concerning age <\/span><\/span><\/span><\/span><\/span>\n\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tSecondary
\n\t\t\thypotheses<\/b><\/span><\/p>\n<\/td>\n

\n

\n\t\t\tThere
\n\t\t\tis no <\/span>differences
\n\t\t\tin higher order aberrations (HOAs) concerning age <\/span><\/span><\/span><\/span><\/span>
\n\t\t\t<\/span>\n\t\t\t<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t
<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tStudy organization<\/b><\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tMaterials \/ devices \/ software<\/b><\/p>\n<\/td>\n

\n

\n\t\t\t–
\n\t\t\t<\/span>Autorefractor
\n\t\t\t(Zeiss iProfiler)<\/span><\/span><\/span><\/span><\/p>\n

\n\t\t\t
<\/p>\n

\n\t\t\t-Phoropter
\n\t\t\t<\/span><\/span><\/span><\/span>\n\t\t\t<\/p>\n

\n\t\t\t
<\/p>\n

\n\t\t\t-Statistical
\n\t\t\tSoftware SPSS<\/span><\/span><\/span><\/span><\/span><\/p>\n

\n\t\t\t
<\/p>\n

\n\t\t\t-Wavefront
\n\t\t\tAberrometer <\/span><\/span>(Zeiss
\n\t\t\tiProfiler)<\/span><\/span><\/span><\/span><\/span><\/p>\n

\n\t\t\t-Patient
\n\t\t\tData Recording System<\/span><\/span><\/p>\n

\n\t\t\t-Clinical
\n\t\t\tExamination Room<\/span><\/span><\/p>\n

-Consent
\n\t\t\tForms and Ethical Approval<\/span><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tSample size<\/b><\/p>\n<\/td>\n

\n

\n\t\t\t–<\/span>Approx.
\n\t\t\t18 participants<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tInclusion &
\n\t\t\texclusion criteria<\/b><\/span><\/p>\n<\/td>\n

\n

\n\t\t\tInclusion
\n\t\t\tcriteria:<\/span><\/p>\n

\n\t\t\tAge
\n\t\t\tRange – Participants aged between 18 and 60 years.<\/span><\/p>\n

\n\t\t\tRefractive
\n\t\t\tError – Both individuals with high refractive error (e.g., myopia,
\n\t\t\thyperopia, astigmatism) and those with normal or low refractive
\n\t\t\terror in range of <\/span>spherical
\n\t\t\trefractive error max \u00b18dpt, cyl max -6dpt<\/p>\n

\n\t\t\tVisual
\n\t\t\tAcuity – Individuals with a best-corrected visual acuity of 20\/20
\n\t\t\tor better.<\/span><\/p>\n

\n\t\t\tGood
\n\t\t\tGeneral Health – Participants without significant systemic or
\n\t\t\tocular health conditions that could affect study outcomes.<\/span><\/p>\n

\n\t\t\tExclusion
\n\t\t\tcriteria<\/span><\/p>\n

\n\t\t\tPrevious
\n\t\t\tEye Surgery – Individuals who have undergone refractive or
\n\t\t\tcataract surgery.<\/span><\/p>\n

\n\t\t\tOcular
\n\t\t\tPathologies – Those with ocular pathologies such as glaucoma,
\n\t\t\tretinal disorders, or corneal abnormalities.<\/span><\/p>\n

\n\t\t\tPregnancy
\n\t\t\t– Exclusion of pregnant women due to potential hormonal influences
\n\t\t\ton the eyes.<\/span><\/p>\n

\n\t\t\tContact
\n\t\t\tLens Wear – Individuals wearing contact lenses to be excluded due
\n\t\t\tto potential effects on wavefront measurements.<\/span><\/p>\n

\n\t\t\tSystemic
\n\t\t\tMedications – Participants on medications known to influence
\n\t\t\tocular parameters.<\/span><\/p>\n

\n\t\t\tInability
\n\t\t\tto Provide Informed Consent – Individuals unable to comprehend the
\n\t\t\tstudy requirements or provide informed consent.<\/span><\/p>\n

\n\t\t\tUncontrolled
\n\t\t\tSystemic Conditions – Exclusion of participants with uncontrolled
\n\t\t\tdiabetes or hypertension.<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tMeasurement
\n\t\t\tprocedure<\/b><\/span><\/p>\n<\/td>\n

\n
    \n
  1. \n

    \n\t\t\t\tParticipant
    \n\t\t\t\tPreparation<\/span><\/p>\n<\/li>\n<\/ol>\n

    \n\t\t\t
    <\/p>\n

      \n
    1. \n

      \n\t\t\t\tAutorefraction
      \n\t\t\t\t( <\/span>Wavefront
      \n\t\t\t\tAberrometer) <\/span><\/span>\n\t\t\t\t<\/p>\n<\/li>\n

    2. \n

      \n\t\t\t\tVA
      \n\t\t\t\ttesting with phoropter<\/span><\/p>\n<\/li>\n

    3. \n

      \n\t\t\t\tData
      \n\t\t\t\tCollection<\/span><\/p>\n<\/li>\n

    4. \n

      \n\t\t\t\tRepeated
      \n\t\t\t\tMeasures (if applicable)<\/span><\/p>\n<\/li>\n

    5. \n

      \n\t\t\t\tData
      \n\t\t\t\tAnalysis<\/span><\/p>\n<\/li>\n

    6. \n

      \n\t\t\t\tQuality
      \n\t\t\t\tControl<\/span><\/p>\n<\/li>\n

    7. \n

      \n\t\t\t\tEthical
      \n\t\t\t\tConsiderations<\/span><\/p>\n<\/li>\n

    8. \n

      Documentation
      \n\t\t\t\tof all measurements after collecting and calculating data<\/span><\/p>\n<\/li>\n<\/ol>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tRandomization<\/b><\/span><\/p>\n<\/td>\n

\n

\n\t\t\tParticipant
\n\t\t\tassignment to specific conditions will be randomized during the
\n\t\t\tmeasurement sessions<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tControl factors<\/b><\/span><\/p>\n<\/td>\n

\n
    \n
  1. \n

    \n\t\t\t\tEnvironmental
    \n\t\t\t\tConditions<\/span><\/p>\n<\/li>\n<\/ol>\n

    \n\t\t\t
    <\/p>\n

      \n
    1. \n

      \n\t\t\t\tTime
      \n\t\t\t\tof Day<\/span><\/p>\n<\/li>\n

    2. \n

      \n\t\t\t\tHead
      \n\t\t\t\tPosition and Alignment<\/span><\/p>\n<\/li>\n

    3. \n

      \n\t\t\t\tHealth
      \n\t\t\t\tStatus<\/span><\/p>\n<\/li>\n

    4. \n

      Consistent
      \n\t\t\t\tMeasurement Techniques<\/span><\/p>\n<\/li>\n<\/ol>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tLimitations<\/b><\/span><\/p>\n<\/td>\n

\n
    \n
  1. \n

    \n\t\t\t\tFatigue<\/span><\/p>\n<\/li>\n<\/ol>\n

    \n\t\t\t
    <\/p>\n

      \n
    1. \n

      \n\t\t\t\tAccommodation<\/span><\/p>\n<\/li>\n

    2. \n

      Previous
      \n\t\t\t\tVisual Tasks e.g. Working on Computer<\/span><\/p>\n<\/li>\n<\/ol>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t
<\/p>\n<\/td>\n

\n

\n\t\t\t
<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tAnalysis<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tPrimary data
\n\t\t\tanalysis<\/b><\/span><\/p>\n<\/td>\n

\n

\n\t\t\tSize of pupil: 3 mm\n\t\t\t<\/p>\n

    \n
  • \n

    \n\t\t\t\tZ (2,-2) Oblique Astigmatis \t<\/p>\n<\/li>\n

  • \n

    \n\t\t\t\tZ (2,0) Defocus\t<\/p>\n<\/li>\n

  • \n

    \n\t\t\t\tZ (2,2) WTR\/ART Astigmatism\t<\/p>\n<\/li>\n

  • \n

    \n\t\t\t\tZ (3,-3) Oblique Trefoil\t<\/p>\n<\/li>\n

  • \n

    \n\t\t\t\tZ (3,-1) Vertical Coma\t<\/p>\n<\/li>\n

  • \n

    \n\t\t\t\tZ (3,1) Horizontal Coma\t<\/p>\n<\/li>\n

  • \n

    Z
    \n\t\t\t\t(3,3) Horizontal Trefoil<\/span><\/p>\n<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tStatistical
\n\t\t\tanalysis<\/b><\/span><\/p>\n<\/td>\n

\n

\n\t\t\t1.
\n\t\t\tNormal distribution?<\/span><\/p>\n

\n\t\t\t\uf0e0 Lilliefors
\n\t\t\ttest<\/span><\/p>\n

\n\t\t\t2.
\n\t\t\tTest for differences between M, J0 and J45 components<\/span><\/p>\n

\n\t\t\teach<\/span><\/p>\n

\n\t\t\t\uf0e0 Bland-Altman
\n\t\t\tanalysis<\/span><\/p>\n

\n\t\t\t\uf0e0 if
\n\t\t\tnormal distribution: 1-way ANOVA<\/span><\/p>\n

\n\t\t\t\uf0e0 if
\n\t\t\tnot: Kruskal-Wallis<\/span><\/p>\n

\n\t\t\t3.
\n\t\t\tTest for differences in time duration<\/span><\/p>\n

\uf0e0 Excell
\n\t\t\ttime calendar<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\t
<\/p>\n<\/td>\n

\n

\n\t\t\t
<\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tProject management<\/b><\/span><\/p>\n<\/td>\n<\/tr>\n

\n

<\/a>
\n\t\t\tTime schedule<\/b><\/span><\/p>\n<\/td>\n

\n

\n\t\t\tStart:
\n\t\t\t02\/2025<\/span><\/p>\n

\n\t\t\t
<\/p>\n

\n\t\t\tEnd:
\n\t\t\t11\/2025<\/span><\/p>\n

\n\t\t\tPreparation:
\n\t\t\t03\/2025<\/span><\/p>\n

\n\t\t\tMeasurements:
\n\t\t\t03\/2025<\/span><\/p>\n

\n\t\t\tAnalysis:
\n\t\t\t10\/2025<\/span><\/p>\n

Writing:
\n\t\t\t11\/2025<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tQM \/ Supervision<\/b><\/span><\/p>\n<\/td>\n

\n

\n\t\t\tMonthly
\n\t\t\tmeeting with supervisor<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tRisk assessment<\/b><\/span><\/p>\n<\/td>\n

\n

\n\t\t\tNo
\n\t\t\trisk for study participant, as only CE certified devices are<\/span><\/p>\n<\/td>\n<\/tr>\n

\n

\n\t\t\tFurther project idea(s)<\/b><\/p>\n<\/td>\n

\n

\n\t\t\tDifference
\n\t\t\tbetwen Oculenz and digital Amblyz\u2122 amblyopia device<\/span><\/p>\n<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

Study description Title Temporal Dynamics of Higher Order Aberrations in the Human Eye: A Comprehensive Study Across Morning and Evening Examiner Illes Tibor Background of the study topic This study delves into the dynamic nature of higher order aberrations (HOAs) in the human eye at different times of the day: morning and evening. HOAs are […]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","template":"","meta":[],"disciplines":[213],"paper_types":[],"tagged":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/questions\/18953"}],"collection":[{"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/questions"}],"about":[{"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/types\/questions"}],"author":[{"embeddable":true,"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/comments?post=18953"}],"version-history":[{"count":0,"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/questions\/18953\/revisions"}],"wp:attachment":[{"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/media?parent=18953"}],"wp:term":[{"taxonomy":"disciplines","embeddable":true,"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/disciplines?post=18953"},{"taxonomy":"paper_types","embeddable":true,"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/paper_types?post=18953"},{"taxonomy":"tagged","embeddable":true,"href":"https:\/\/www.writemyessays.app\/blog\/wp-json\/wp\/v2\/tagged?post=18953"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}