An introduction a literature review (Comparing the Efficacy and Safety of Spinraza to Other Treatment Options for Spinal Muscular Atrophy: A Systematic Review.)

I have research paper titled 

(Comparing the Efficacy and Safety of Spinraza to Other Treatment
Options for Spinal Muscular Atrophy: A Systematic Review.)
I would like you to write the introduction and a small literature review 
I will upload the appropriate data for the introduction with similar articles for what I am aiming for 
I would like the Literature review to be divided into three thirds 
One third from data from the international database 
One third from the Middle East and North Africa region 
And the last third from the Gulf region, specifically Saudi Arabia.
Only use Recent data please from 3 to 5 years
I have attached similar articles and will attach the research protocol as well 

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